ngl the previous reply nailed it, but I'd push back slightly on one thing: vanilla alchemy absolutely works, you just have to actually use the poisons instead of hoarding them like they're precious artifacts. Most players craft a paralysis poison, get nervous about "wasting" it, and never touch it. Then they wonder why alchemy feels useless.
The real power spike is less about specific perks and more about understanding what actually matters in fights. Paralysis on a weapon or arrow turns almost any encounter trivial - especially against melee enemies. Damage health potions are solid too but honestly paralysis is where the cheese lives. Even at level 32 you can make decent ones if you've got the right ingredients.
That said - yeah, if you're on PC and willing to mod, Ordinator makes alchemy actually fun instead of just functional. But if you're vanilla, you don't need fancy perks to see results. Just grab the poison-effect perks and stop being scared to actually use what you make.
What's your character built for? If you're melee, paralysis poisons on daggers or arrows solve most problems. If you're a mage, fortify magicka/magicka regen potions during tough fights is legitimately clutch. Stealth obviously gets the most mileage since you can poison everything before combat even starts.